RTES-08 Resource control.indd

RTES-08 Resource control.indd

RTES-08 Resource control.indd

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Murine neonatal recent thymic emigrants are phenotypically and functionally distinct from adult recent thymic emigrants.

In contrast to adults, the murine neonatal CD4+ compartment contains a high frequency of recent thymic emigrants (RTEs). However, the functional capabilities of these cells in neonates are relatively unknown. Moreover, it has not been determined whether RTEs from neonates and adults are comparable. Here we have directly compared neonatal and adult CD4+ RTEs for the first time, using a transgeni...

Thymic output in aged mice.

Using GFP to mark recent thymic emigrants (RTEs) in mice carrying a GFP transgene driven by the recombination-activating gene 2 promoter, we demonstrate that RTEs are readily detectable even in 2-year-old mice, despite the fact that the proportion of the peripheral T cell pool comprised of RTEs declines with age. Although the number of RTEs decreases after reaching a peak at 6 weeks of age, thy...

Dll1 and Dll4: similar, but not the same.

and analysis of T cell–receptor rearrangement excision circles. Each of these methods is problematic: they either result in cell death, thereby precluding functional analyses , or involve surgical manipulation that can alter the very parameters being measured. Recent advances have highlighted new means of identifying RTEs in both unmanipu-lated mice and humans, allowing the isolation of live RT...